Human Papillomavirus Type 16 E6 Induces Self-Ubiquitination of the E6AP Ubiquitin-Protein Ligase

The E6 protein of the high-risk human papillomaviruses (HPVs) and the cellular ubiquitin-protein ligase E6AP form a complex which causes the ubiquitination and degradation of p53. We show here that HPV16 E6 promotes the ubiquitination and degradation of E6AP itself. The half-life of E6AP is shorter...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Kao, Wynn H., Beaudenon, Sylvie L., Talis, Andrea L., Huibregtse, Jon M., Howley, Peter M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Transformation and Oncogenesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112148/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10864652/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.14.6408-6417.2000
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