Glycosphingolipids Promote Entry of a Broad Range of Human Immunodeficiency Virus Type 1 Isolates into Cell Lines Expressing CD4, CXCR4, and/or CCR5

Treatment of human osteosarcoma cells, expressing CD4 and various chemokine receptors, with the glucosylceramide synthase inhibitor 1-phenyl-2-hexadecanoylamino-3-morpholino-1-propanol (PPMP), blocked target membrane glycosphingolipid (GSL) biosynthesis and reduced the susceptibility of cells to inf...

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Detalhes bibliográficos
Main Authors: Hug, Peter, Lin, Han-Ming Joseph, Korte, Thomas, Xiao, Xiaodong, Dimitrov, Dimiter S., Wang, Ji Ming, Puri, Anu, Blumenthal, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC112144/
https://ncbi.nlm.nih.gov/pubmed/10864648
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