Isolation and Characterization of Monoclonal Antibodies That Inhibit Hepatitis C Virus NS3 Protease

A series of mouse monoclonal antibodies (MAbs) to the nonstructural protein 3 (NS3) of hepatitis C virus was prepared. One of these MAbs, designated 8D4, was found to inhibit NS3 protease activity. This inhibition was competitive with respect to the substrate peptide (K(i) = 39 nM) but was significa...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Ueno, Takamasa, Misawa, Satoru, Ohba, Yoichi, Matsumoto, Mitsuhiro, Mizunuma, Makiko, Kasai, Nobuhiro, Tsumoto, Kouhei, Kumagai, Izumi, Hayashi, Hideya
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Replication
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112135/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10864639/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.14.6300-6308.2000
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