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Optimized Viral Dose and Transient Immunosuppression Enable Herpes Simplex Virus ICP0-Null Mutants To Establish Wild-Type Levels of Latency In Vivo

The reduced efficiency with which herpes simplex virus type 1 (HSV-1) mutants establish latent infections in vivo has been a fundamental obstacle in efforts to determine the roles of individual viral genes in HSV-1 reactivation. For example, in the absence of the “nonessential” viral immediate-early...

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Detalhes bibliográficos
Publicado no:J Virol
Principais autores: Halford, William P., Schaffer, Priscilla A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112092/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10846077/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.13.5957-5967.2000
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