Octamerization Enables Soluble CD46 Receptor To Neutralize Measles Virus In Vitro and In Vivo

A chimeric fusion protein encompassing the CD46 ectodomain linked to the C-terminal part of the C4b binding protein (C4bp) α chain (sCD46-C4bpα) was produced in eukaryotic cells. This protein, secreted as a disulfide-linked homo-octamer, was recognized by a panel of anti-CD46 antibodies with varying...

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Autori principali: Christiansen, Dale, Devaux, Patricia, Réveil, Brigitte, Evlashev, Alexey, Horvat, Branka, Lamy, Josette, Rabourdin-Combe, Chantal, Cohen, Jacques H. M., Gerlier, Denis
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2000
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC111988/
https://ncbi.nlm.nih.gov/pubmed/10775604
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