Octamerization Enables Soluble CD46 Receptor To Neutralize Measles Virus In Vitro and In Vivo

A chimeric fusion protein encompassing the CD46 ectodomain linked to the C-terminal part of the C4b binding protein (C4bp) α chain (sCD46-C4bpα) was produced in eukaryotic cells. This protein, secreted as a disulfide-linked homo-octamer, was recognized by a panel of anti-CD46 antibodies with varying...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Christiansen, Dale, Devaux, Patricia, Réveil, Brigitte, Evlashev, Alexey, Horvat, Branka, Lamy, Josette, Rabourdin-Combe, Chantal, Cohen, Jacques H. M., Gerlier, Denis
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Vaccines and Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111988/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10775604/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.10.4672-4678.2000
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