Identification of a Key Target Sequence To Block Human Immunodeficiency Virus Type 1 Replication within the gag-pol Transframe Domain

Although the full sequence of the human immunodeficiency virus type 1 (HIV-1) genome has been known for more than a decade, effective genetic antivirals have yet to be developed. Here we show that, of 22 regions examined, one highly conserved sequence (ACTCTTTGGCAACGA) near the 3′ end of the HIV-1 g...

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Autores principales: Sei, Shizuko, Yang, Quan-en, O'Neill, Dennis, Yoshimura, Kazuhisa, Nagashima, Kunio, Mitsuya, Hiroaki
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2000
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC111982/
https://ncbi.nlm.nih.gov/pubmed/10775598
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