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Rescue of Multiple Viral Functions by a Second-Site Suppressor of a Human Immunodeficiency Virus Type 1 Nucleocapsid Mutation

Human immunodeficiency type 1 (HIV-1) bearing the nucleocapsid (NC) mutation R10A/K11A is replication defective. After serial passage of the mutant virus in tissue culture, we isolated a revertant that retained the original mutation. It had acquired, in addition, a new mutation (E21K) that was forma...

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Udgivet i:J Virol
Principais autores: Cimarelli, Andrea, Sandin, Sara, Höglund, Stefan, Luban, Jeremy
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2000
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111944/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10756042/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.9.4273-4283.2000
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