A Single Amino Acid Change in nsP1 Attenuates Neurovirulence of the Sindbis-Group Alphavirus S.A.AR86

S.A.AR86, a member of the Sindbis group of alphaviruses, is neurovirulent in adult mice and has a unique threonine at position 538 of nsP1; nonneurovirulent members of this group of alphaviruses encode isoleucine. Isoleucine was introduced at position 538 in the wild-type S.A.AR86 infectious clone,...

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Publié dans:	J Virol
Auteurs principaux:	Heise, Mark T., Simpson, Dennis A., Johnston, Robert E.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2000
Sujets:	Pathogenesis and Immunity
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111935/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10756033/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.9.4207-4213.2000
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