Mutations in the 2C Region of Poliovirus Responsible for Altered Sensitivity to Benzimidazole Derivatives

MRL-1237, [1-(4-fluorophenyl)-2-(4-imino-1,4-dihydropyridin-1-yl) methylbenzimidazole hydrochloride], is a potent and selective inhibitor of the replication of enteroviruses. To reveal the target molecule of MRL-1237 in viral replication, we selected spontaneous MRL-1237-resistant poliovirus mutants...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Shimizu, Hiroyuki, Agoh, Masanobu, Agoh, Yumi, Yoshida, Hiromu, Yoshii, Kumiko, Yoneyama, Tetsuo, Hagiwara, Akio, Miyamura, Tatsuo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Vaccines and Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111929/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10756027/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.9.4146-4154.2000
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