Mutations in the 2C Region of Poliovirus Responsible for Altered Sensitivity to Benzimidazole Derivatives

MRL-1237, [1-(4-fluorophenyl)-2-(4-imino-1,4-dihydropyridin-1-yl) methylbenzimidazole hydrochloride], is a potent and selective inhibitor of the replication of enteroviruses. To reveal the target molecule of MRL-1237 in viral replication, we selected spontaneous MRL-1237-resistant poliovirus mutants...

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Bibliographic Details
Main Authors: Shimizu, Hiroyuki, Agoh, Masanobu, Agoh, Yumi, Yoshida, Hiromu, Yoshii, Kumiko, Yoneyama, Tetsuo, Hagiwara, Akio, Miyamura, Tatsuo
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC111929/
https://ncbi.nlm.nih.gov/pubmed/10756027
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