Roles of Adeno-Associated Virus Rep Protein and Human Chromosome 19 in Site-Specific Recombination

Adeno-associated virus type 2 (AAV) is the only known eucaryotic virus capable of targeted integration in human cells. AAV integrates preferentially into human chromosome (ch) 19q13.3qter. The nonstructural proteins of AAV-2, Rep78 and Rep68, are essential for targeted integration. Rep78 and Rep68 a...

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Podrobná bibliografie

Vydáno v:	J Virol
Hlavní autoři:	Young, Samuel M., McCarty, Douglas M., Degtyareva, Natalya, Samulski, Richard Jude
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2000
Témata:	Recombination and Evolution
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111909/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10756007/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.9.3953-3966.2000
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