Roles of Adeno-Associated Virus Rep Protein and Human Chromosome 19 in Site-Specific Recombination

Adeno-associated virus type 2 (AAV) is the only known eucaryotic virus capable of targeted integration in human cells. AAV integrates preferentially into human chromosome (ch) 19q13.3qter. The nonstructural proteins of AAV-2, Rep78 and Rep68, are essential for targeted integration. Rep78 and Rep68 a...

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Bibliografiska uppgifter
Huvudupphovsmän: Young, Samuel M., McCarty, Douglas M., Degtyareva, Natalya, Samulski, Richard Jude
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2000
Ämnen:
Recombination and Evolution
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC111909/
https://ncbi.nlm.nih.gov/pubmed/10756007
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