Attenuated, Replication-Competent Herpes Simplex Virus Type 1 Mutant G207: Safety Evaluation in Mice

Herpes simplex virus type 1 (HSV-1) mutants that are attenuated for neurovirulence are being used for the treatment of cancer. We have examined the safety of G207, a multimutated replication-competent HSV-1 vector, in mice. BALB/c mice inoculated intracerebrally or intracerebroventricularly with 10(...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Sundaresan, Periasamy, Hunter, William D., Martuza, Robert L., Rabkin, Samuel D.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Pathogenesis and Immunity
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111891/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10729157/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.8.3832-3841.2000
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