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Identification of Amino Acid Residues in CD81 Critical for Interaction with Hepatitis C Virus Envelope Glycoprotein E2

Human CD81 has been previously identified as the putative receptor for the hepatitis C virus envelope glycoprotein E2. The large extracellular loop (LEL) of human CD81 differs in four amino acid residues from that of the African green monkey (AGM), which does not bind E2. We mutated each of the four...

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Published in:J Virol
Main Authors: Higginbottom, Adrian, Quinn, Elizabeth R., Kuo, Chiung-Chi, Flint, Mike, Wilson, Louise H., Bianchi, Elisabetta, Nicosia, Alfredo, Monk, Peter N., McKeating, Jane A., Levy, Shoshana
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2000
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111874/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10729140/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.8.3642-3649.2000
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