Functional Analysis of Cell Surface-Expressed Hepatitis C Virus E2 Glycoprotein

Hepatitis C virus (HCV) glycoproteins E1 and E2, when expressed in eukaryotic cells, are retained in the endoplasmic reticulum (ER). C-terminal truncation of E2 at residue 661 or 715 (position on the polyprotein) leads to secretion, consistent with deletion of a proposed hydrophobic transmembrane an...

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Autori principali: Flint, Mike, Thomas, Joanne M., Maidens, Catherine M., Shotton, Christine, Levy, Shoshana, Barclay, Wendy S., McKeating, Jane A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 1999
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC112763/
https://ncbi.nlm.nih.gov/pubmed/10400776
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