Virus-Induced Diabetes in a Transgenic Model: Role of Cross-Reacting Viruses and Quantitation of Effector T Cells Needed To Cause Disease

Virus-specific cytotoxic T lymphocytes (CTL) at frequencies of >1/1,000 are sufficient to cause insulin-dependent diabetes mellitus (IDDM) in transgenic mice whose pancreatic β cells express as “self” antigen a protein from a virus later used to initiate infection. The inability to generate sufficie...

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Pubblicato in:	J Virol
Autori principali:	Sevilla, Noemi, Homann, Dirk, von Herrath, Matthias, Rodriguez, Fernando, Harkins, Stephanie, Whitton, J. Lindsay, Oldstone, Michael B. A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Pathogenesis and Immunity
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111829/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10708445/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.7.3284-3292.2000
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