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DNA Methylation of Helper Virus Increases Genetic Instability of Retroviral Vector Producer Cells

Retroviral vector producer cells (VPC) have been considered genetically stable. A clonal cell population exhibiting a uniform vector integration pattern is used for sustained vector production. Here, we observed that the vector copy number is increased and varied in a population of established LTKOS...

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Autori principali: Young, Won-Bin, Lindberg, Gary L., Link, Charles J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC111818/
https://ncbi.nlm.nih.gov/pubmed/10708434
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