DNA Methylation of Helper Virus Increases Genetic Instability of Retroviral Vector Producer Cells

Retroviral vector producer cells (VPC) have been considered genetically stable. A clonal cell population exhibiting a uniform vector integration pattern is used for sustained vector production. Here, we observed that the vector copy number is increased and varied in a population of established LTKOS...

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Pubblicato in:	J Virol
Autori principali:	Young, Won-Bin, Lindberg, Gary L., Link, Charles J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Gene Therapy
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111818/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10708434/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.7.3177-3187.2000
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