Hypervariable Region 1 Sequence Stability during Hepatitis C Virus Replication in Chimpanzees

The putative envelope 2 (E2) gene of hepatitis C virus (HCV) contains a highly variable region referred to as hypervariable region 1 (HVR1). We hypothesized that this genetic variability is driven by immune selection pressure, rather than representing the accumulation of random mutations in a region...

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הוצא לאור ב:	J Virol
Principais autores:	Ray, Stuart C., Mao, Qing, Lanford, Robert E., Bassett, Suzanne, Laeyendecker, Oliver, Wang, Yu-Ming, Thomas, David L.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	American Society for Microbiology (ASM) 2000
נושאים:	Pathogenesis and Immunity
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111804/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10708420/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.7.3058-3066.2000
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