Hypervariable Region 1 Sequence Stability during Hepatitis C Virus Replication in Chimpanzees

The putative envelope 2 (E2) gene of hepatitis C virus (HCV) contains a highly variable region referred to as hypervariable region 1 (HVR1). We hypothesized that this genetic variability is driven by immune selection pressure, rather than representing the accumulation of random mutations in a region...

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Main Authors: Ray, Stuart C., Mao, Qing, Lanford, Robert E., Bassett, Suzanne, Laeyendecker, Oliver, Wang, Yu-Ming, Thomas, David L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC111804/
https://ncbi.nlm.nih.gov/pubmed/10708420
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