Nef-Induced Major Histocompatibility Complex Class I Down-Regulation Is Functionally Dissociated from Its Virion Incorporation, Enhancement of Viral Infectivity, and CD4 Down-Regulation

The N-terminal alpha-helix domain of the human immunodeficiency virus type 1 (HIV-1) Nef protein plays important roles in enhancement of viral infectivity, virion incorporation of Nef, and the down-regulation of major histocompatibility complex class I (MHC-I) expression on cell surfaces. In this st...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Akari, Hirofumi, Arold, Stefan, Fukumori, Tomoharu, Okazaki, Toshiyuki, Strebel, Klaus, Adachi, Akio
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Virus-Cell Interactions
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111784/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10684310/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.6.2907-2912.2000
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