Long-Term Transgene Expression in Mice Infected with a Herpes Simplex Virus Type 1 Mutant Severely Impaired for Immediate-Early Gene Expression

The role of viral immediate-early (IE) gene expression in herpes simplex virus type 1 (HSV-1) latency was investigated. The HSV-1 multiple mutant in1312, defective for the expression of the virion transactivator VP16 and the IE proteins ICP0 and ICP4, was used as the parent for these studies. The co...

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Εκδόθηκε σε:	J Virol
Κύριοι συγγραφείς:	Marshall, Ker R., Lachmann, Robin H., Efstathiou, Stacey, Rinaldi, Angela, Preston, Chris M.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 2000
Θέματα:	Gene Therapy
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111616/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10623758/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.2.956-964.2000
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