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Long-Term Transgene Expression in Mice Infected with a Herpes Simplex Virus Type 1 Mutant Severely Impaired for Immediate-Early Gene Expression

The role of viral immediate-early (IE) gene expression in herpes simplex virus type 1 (HSV-1) latency was investigated. The HSV-1 multiple mutant in1312, defective for the expression of the virion transactivator VP16 and the IE proteins ICP0 and ICP4, was used as the parent for these studies. The co...

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Библиографические подробности
Главные авторы: Marshall, Ker R., Lachmann, Robin H., Efstathiou, Stacey, Rinaldi, Angela, Preston, Chris M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2000
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC111616/
https://ncbi.nlm.nih.gov/pubmed/10623758
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