Development of Human T-Cell Leukemia Virus Type 1-Transformed Tumors in Rats following Suppression of T-Cell Immunity by CD80 and CD86 Blockade

Host immunity influences clinical manifestations of human T-cell leukemia virus type 1 (HTLV-1) infection. In this study, we demonstrated that HTLV-1-transformed tumors could develop in immunocompetent rats by blocking a costimulatory signal for T-cell immune responses. Four-week-old WKA/HKm rats we...

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Publié dans:	J Virol
Auteurs principaux:	Hanabuchi, Shino, Ohashi, Takashi, Koya, Yoshihiro, Kato, Hirotomo, Takemura, Fumiyo, Hirokawa, Katsuiku, Yoshiki, Takashi, Yagita, Hideo, Okumura, Ko, Kannagi, Mari
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2000
Sujets:	Pathogenesis and Immunity
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111554/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10590132/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.1.428-435.2000
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