Development of Human T-Cell Leukemia Virus Type 1-Transformed Tumors in Rats following Suppression of T-Cell Immunity by CD80 and CD86 Blockade

Host immunity influences clinical manifestations of human T-cell leukemia virus type 1 (HTLV-1) infection. In this study, we demonstrated that HTLV-1-transformed tumors could develop in immunocompetent rats by blocking a costimulatory signal for T-cell immune responses. Four-week-old WKA/HKm rats we...

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Hauptverfasser: Hanabuchi, Shino, Ohashi, Takashi, Koya, Yoshihiro, Kato, Hirotomo, Takemura, Fumiyo, Hirokawa, Katsuiku, Yoshiki, Takashi, Yagita, Hideo, Okumura, Ko, Kannagi, Mari
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC111554/
https://ncbi.nlm.nih.gov/pubmed/10590132
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