B7 Costimulation Is Critical for Antibody Class Switching and CD8(+) Cytotoxic T-Lymphocyte Generation in the Host Response to Vesicular Stomatitis Virus

Antibody and cytotoxic T-lymphocyte (CTL) responses have critical roles in eliminating many viral infections. In addition to stimulation of the T-cell receptor, T cells require costimulatory signals to respond optimally. We evaluated the role of B7 costimulatory molecules (B7-1 and B7-2) in the immu...

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Bibliographic Details
Main Authors: McAdam, Alexander J., Farkash, Evan A., Gewurz, Benjamin E., Sharpe, Arlene H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC111529/
https://ncbi.nlm.nih.gov/pubmed/10590107
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