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The Disappearance of Cyclins A and B and the Increase in Activity of the G(2)/M-Phase Cellular Kinase cdc2 in Herpes Simplex Virus 1-Infected Cells Require Expression of the α22/U(S)1.5 and U(L)13 Viral Genes

In uninfected cells the G(2)/M transition is regulated by cyclin kinase complex containing cdc2 and, initially, cyclin A, followed by cyclin B. cdc2 is downregulated through phosphorylation by wee-1 and myt-1 and upregulated by cdc-25C phosphatase. We have examined the accumulation and activities of...

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Autors principals: Advani, S. J., Brandimarti, R., Weichselbaum, R. R., Roizman, B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC111507/
https://ncbi.nlm.nih.gov/pubmed/10590085
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