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Repeat Transduction in the Mouse Lung by Using Adeno-Associated Virus Vectors with Different Serotypes

Vectors derived from adeno-associated virus type 2 (AAV2) promote gene transfer and expression in the lung; however, we have found that while gene expression can persist for at least 8 months in mice, it was reduced dramatically in rabbits over a period of 2 months. The efficiency and persistence of...

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Udgivet i:J Virol
Principais autores: Halbert, Christine L., Rutledge, Elizabeth A., Allen, James M., Russell, David W., Miller, A. Dusty
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2000
Fag:
Gene Therapy
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111488/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10627564/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.3.1524-1532.2000
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