Structure-Activity Analysis of Microcin J25: Distinct Parts of the Threaded Lasso Molecule Are Responsible for Interaction with Bacterial RNA Polymerase

Peptide microcin J25 (MccJ25) inhibits bacterial RNA polymerase. We show that thermolysin-cleaved MccJ25 and MccJ25 lacking amino acids 13 to 17 also inhibit transcription. Our data and structural analysis of intact and thermolysin-digested MccJ25 suggest that distinct regions of MccJ25 are involved...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Semenova, Ekaterina, Yuzenkova, Yulia, Peduzzi, Jean, Rebuffat, Sylvie, Severinov, Konstantin
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2005
Ämnen:
Genetics and Molecular Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1112051/
https://ncbi.nlm.nih.gov/pubmed/15901712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.187.11.3859-3863.2005
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