Phase 1 Clinical Trial of Apical Membrane Antigen 1: an Asexual Blood-Stage Vaccine for Plasmodium falciparum Malaria

Apical membrane antigen 1 (AMA1), a polymorphic merozoite surface protein, is a leading blood-stage malaria vaccine candidate. A phase 1 trial was conducted with 30 malaria-naïve volunteers to assess the safety and immunogenicity of the AMA1-C1 malaria vaccine. AMA1-C1 contains an equal mixture of r...

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Main Authors: Malkin, Elissa M., Diemert, David J., McArthur, Julie H., Perreault, John R., Miles, Aaron P., Giersing, Birgitte K., Mullen, Gregory E., Orcutt, Andrew, Muratova, Olga, Awkal, May, Zhou, Hong, Wang, Jin, Stowers, Anthony, Long, Carole A., Mahanty, Siddhartha, Miller, Louis H., Saul, Allan, Durbin, Anna P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Fungal and Parasitic Infections
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1111886/
https://ncbi.nlm.nih.gov/pubmed/15908397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.6.3677-3685.2005
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