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Effects of RNA secondary structure on cellular antisense activity

The secondary and tertiary structures of a mRNA are known to effect hybridization efficiency and potency of antisense oligonucleotides in vitro. Additional factors including oligonucleotide stability and cellular uptake are also thought to contribute to antisense potency in vivo. Each of these facto...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
I whakaputaina i:Nucleic Acids Res
Ngā kaituhi matua: Vickers, Timothy A., Wyatt, Jacqueline R., Freier, Susan M.
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Oxford University Press 2000
Ngā marau:
Urunga tuihono:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111043/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10684928/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.6.1340
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