Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria

An enzyme activity introducing an alkali-labile site at 2-hydroxyadenine (2-OH-A) in double-stranded oligonucleotides was detected in nuclear extracts of Jurkat cells. This activity co-eluted with activities toward adenine paired with guanine and 8-oxo-7,8-dihydroguanine (8-oxoG) as a single peak co...

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Hauptverfasser: Ohtsubo, Toshio, Nishioka, Kenichi, Imaiso, Yasuyuki, Iwai, Shigenori, Shimokawa, Hidetoshi, Oda, Hisanobu, Fujiwara, Toshiyuki, Nakabeppu, Yusaku
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2000
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC111038/
https://ncbi.nlm.nih.gov/pubmed/10684930
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