Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria

An enzyme activity introducing an alkali-labile site at 2-hydroxyadenine (2-OH-A) in double-stranded oligonucleotides was detected in nuclear extracts of Jurkat cells. This activity co-eluted with activities toward adenine paired with guanine and 8-oxo-7,8-dihydroguanine (8-oxoG) as a single peak co...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Ohtsubo, Toshio, Nishioka, Kenichi, Imaiso, Yasuyuki, Iwai, Shigenori, Shimokawa, Hidetoshi, Oda, Hisanobu, Fujiwara, Toshiyuki, Nakabeppu, Yusaku
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2000
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111038/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10684930/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.6.1355
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