Mutation analysis of the CHK2 gene in breast carcinoma and other cancers

BACKGROUND: Mutations in the CHK2 gene at chromosome 22q12.1 have been reported in families with Li-Fraumeni syndrome. Chk2 is an effector kinase that is activated in response to DNA damage and is involved in cell-cycle pathways and p53 pathways. METHODS: We screened 139 breast tumors for loss of he...

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Main Authors: Ingvarsson, Sigurdur, Sigbjornsdottir, Bjarnveig I, Huiping, Chen, Hafsteinsdottir, Sigridur H, Ragnarsson, Gisli, Barkardottir, Rosa B, Arason, Adalgeir, Egilsson, Valgardur, Bergthorsson, Jon TH
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2002
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC111029/
https://ncbi.nlm.nih.gov/pubmed/12052256
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