Oxazolidinone Resistance Mutations in 23S rRNA of Escherichia coli Reveal the Central Region of Domain V as the Primary Site of Drug Action

Oxazolidinone antibiotics inhibit bacterial protein synthesis by interacting with the large ribosomal subunit. The structure and exact location of the oxazolidinone binding site remain obscure, as does the manner in which these drugs inhibit translation. To investigate the drug-ribosome interaction,...

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Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Xiong, Liqun, Kloss, Patricia, Douthwaite, Stephen, Andersen, Niels Møller, Swaney, Steven, Shinabarger, Dean L., Mankin, Alexander S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Genetics and Molecular Biology
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110973/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10986233/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.182.19.5325-5331.2000
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