Oxazolidinone Resistance Mutations in 23S rRNA of Escherichia coli Reveal the Central Region of Domain V as the Primary Site of Drug Action

Oxazolidinone antibiotics inhibit bacterial protein synthesis by interacting with the large ribosomal subunit. The structure and exact location of the oxazolidinone binding site remain obscure, as does the manner in which these drugs inhibit translation. To investigate the drug-ribosome interaction,...

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Bibliografische gegevens

Gepubliceerd in:	J Bacteriol
Hoofdauteurs:	Xiong, Liqun, Kloss, Patricia, Douthwaite, Stephen, Andersen, Niels Møller, Swaney, Steven, Shinabarger, Dean L., Mankin, Alexander S.
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 2000
Onderwerpen:	Genetics and Molecular Biology
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110973/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10986233/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.182.19.5325-5331.2000
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