Hepatitis C Virus Internal Ribosome Entry Site (IRES) Stem Loop IIId Contains a Phylogenetically Conserved GGG Triplet Essential for Translation and IRES Folding

The hepatitis C virus (HCV) internal ribosome entry site (IRES) is a highly structured RNA element that directs cap-independent translation of the viral polyprotein. Morpholino antisense oligonucleotides directed towards stem loop IIId drastically reduced HCV IRES activity. Mutagenesis studies of th...

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Detalhes bibliográficos
Main Authors: Jubin, Ronald, Vantuno, Nicole E., Kieft, Jeffrey S., Murray, Michael G., Doudna, Jennifer A., Lau, Johnson Y. N., Baroudy, Bahige M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC110917/
https://ncbi.nlm.nih.gov/pubmed/11044087
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