Hepatitis C Virus Internal Ribosome Entry Site (IRES) Stem Loop IIId Contains a Phylogenetically Conserved GGG Triplet Essential for Translation and IRES Folding

The hepatitis C virus (HCV) internal ribosome entry site (IRES) is a highly structured RNA element that directs cap-independent translation of the viral polyprotein. Morpholino antisense oligonucleotides directed towards stem loop IIId drastically reduced HCV IRES activity. Mutagenesis studies of th...

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Pubblicato in:	J Virol
Autori principali:	Jubin, Ronald, Vantuno, Nicole E., Kieft, Jeffrey S., Murray, Michael G., Doudna, Jennifer A., Lau, Johnson Y. N., Baroudy, Bahige M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Replication
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110917/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11044087/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.22.10430-10437.2000
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