Major Histocompatibility Complex Class I Gene Controls the Generation of Gamma Interferon-Producing CD4(+) and CD8(+) T Cells Important for Recovery from Friend Retrovirus-Induced Leukemia

Recovery from leukemia induced by Friend virus complex (FV) requires strong CD4(+) helper, CD8(+) cytotoxic T-lymphocyte, and B-cell responses. The development of these immune responses is dependent on the major histocompatibility complex (MHC) (H-2) genotype of the mouse. In H-2(b/b) mice, which sp...

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Bibliographic Details
Main Authors: Peterson, Karin E., Iwashiro, Michihiro, Hasenkrug, Kim J., Chesebro, Bruce
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC110893/
https://ncbi.nlm.nih.gov/pubmed/10799615
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