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Fourteen Residues of the U1 snRNP-Specific U1A Protein Are Required for Homodimerization, Cooperative RNA Binding, and Inhibition of Polyadenylation

It was previously shown that the human U1A protein, one of three U1 small nuclear ribonucleoprotein-specific proteins, autoregulates its own production by binding to and inhibiting the polyadenylation of its own pre-mRNA. The U1A autoregulatory complex requires two molecules of U1A protein to cooper...

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Izdano u:Mol Cell Biol
Glavni autori: Klein Gunnewiek, Jacqueline M. T., Hussein, Reem I., van Aarssen, Yvonne, Palacios, Daphne, de Jong, Rob, van Venrooij, Walther J., Gunderson, Samuel I.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2000
Teme:
Gene Expression
Online pristup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110837/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10688667/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.6.2209-2217.2000
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