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High efficiency family shuffling based on multi-step PCR and in vivo DNA recombination in yeast: statistical and functional analysis of a combinatorial library between human cytochrome P450 1A1 and 1A2

The design of a family shuffling strategy (CLERY: Combinatorial Libraries Enhanced by Recombination in Yeast) associating PCR-based and in vivo recombination and expression in yeast is described. This strategy was tested using human cytochrome P450 CYP1A1 and CYP1A2 as templates, which share 74% nuc...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Abécassis, Valérie, Pompon, Denis, Truan, Gilles
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2000
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC110804/
https://ncbi.nlm.nih.gov/pubmed/11024190
תגים: הוספת תג
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