Hammerhead ribozymes selectively suppress mutant type I collagen mRNA in osteogenesis imperfecta fibroblasts

Ribozymes are a promising agent for the gene therapy of dominant negative genetic disorders by allele-specific mRNA suppression. To test allele-specific mRNA suppression in cells, we used fibroblasts from a patient with osteogenesis imperfecta (OI). These cells contain a mutation in one α1(I) collag...

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Argitaratua izan da:	Nucleic Acids Res
Egile Nagusiak:	Dawson, Paul A., Marini, Joan C.
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Oxford University Press 2000
Gaiak:	Article
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110781/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11024182/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.20.4013
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