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DNA-binding mechanism of the Escherichia coli Ada O(6)-alkylguanine–DNA alkyltransferase

The C-terminal domain of the Escherichia coli Ada protein (Ada-C) aids in the maintenance of genomic integrity by efficiently repairing pre-mutagenic O(6)-alkylguanine lesions in DNA. Structural and thermodynamic studies were carried out to obtain a model of the DNA-binding process. Nuclear magnetic...

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Autors principals: Verdemato, Philip E., Brannigan, James A., Damblon, Christian, Zuccotto, Fabio, Moody, Peter C. E., Lian, Lu-Yun
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC110768/
https://ncbi.nlm.nih.gov/pubmed/11000262
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