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Holliday junction resolvases and related nucleases: identification of new families, phyletic distribution and evolutionary trajectories

Holliday junction resolvases (HJRs) are key enzymes of DNA recombination. A detailed computer analysis of the structural and evolutionary relationships of HJRs and related nucleases suggests that the HJR function has evolved independently from at least four distinct structural folds, namely RNase H,...

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Main Authors: Aravind, L., Makarova, Kira S., Koonin, Eugene V.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2000
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC110722/
https://ncbi.nlm.nih.gov/pubmed/10982859
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