Functional significance of conserved residues in the phosphohydrolase module of Escherichia coli MutT protein

Escherichia coli MutT protein hydrolyzes 8-oxo-7,8-dihydro-2′-dGTP (8-oxo-dGTP) to the monophosphate, thus avoiding the incorporation of 8-oxo-7,8-dihydroguanine (8-oxo-G) into nascent DNA. Bacterial and mammalian homologs of MutT protein share the phosphohydrolase module (MutT: Gly37→Gly59). By sat...

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Main Authors: Shimokawa, Hidetoshi, Fujii, Yoshimitsu, Furuichi, Masato, Sekiguchi, Mutsuo, Nakabeppu, Yusaku
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2000
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC110708/
https://ncbi.nlm.nih.gov/pubmed/10954591
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