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Functional significance of conserved residues in the phosphohydrolase module of Escherichia coli MutT protein

Escherichia coli MutT protein hydrolyzes 8-oxo-7,8-dihydro-2′-dGTP (8-oxo-dGTP) to the monophosphate, thus avoiding the incorporation of 8-oxo-7,8-dihydroguanine (8-oxo-G) into nascent DNA. Bacterial and mammalian homologs of MutT protein share the phosphohydrolase module (MutT: Gly37→Gly59). By sat...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
I whakaputaina i:Nucleic Acids Res
Ngā kaituhi matua: Shimokawa, Hidetoshi, Fujii, Yoshimitsu, Furuichi, Masato, Sekiguchi, Mutsuo, Nakabeppu, Yusaku
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Oxford University Press 2000
Ngā marau:
Urunga tuihono:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110708/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10954591/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.17.3240
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