Functional significance of conserved residues in the phosphohydrolase module of Escherichia coli MutT protein

Escherichia coli MutT protein hydrolyzes 8-oxo-7,8-dihydro-2′-dGTP (8-oxo-dGTP) to the monophosphate, thus avoiding the incorporation of 8-oxo-7,8-dihydroguanine (8-oxo-G) into nascent DNA. Bacterial and mammalian homologs of MutT protein share the phosphohydrolase module (MutT: Gly37→Gly59). By sat...

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發表在:	Nucleic Acids Res
Principais autores:	Shimokawa, Hidetoshi, Fujii, Yoshimitsu, Furuichi, Masato, Sekiguchi, Mutsuo, Nakabeppu, Yusaku
格式:	Artigo
語言:	Inglês
出版:	Oxford University Press 2000
主題:	Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110708/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10954591/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.17.3240
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