Laron Dwarfism and Non-Insulin-Dependent Diabetes Mellitus in the Hnf-1α Knockout Mouse

Mice deficient in hepatocyte nuclear factor 1 alpha (HNF-1α) were produced by use of the Cre-loxP recombination system. HNF-1α-null mice are viable but sterile and exhibit a phenotype reminiscent of both Laron-type dwarfism and non-insulin-dependent diabetes mellitus (NIDDM). In contrast to an earli...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Lee, Ying-Hue, Sauer, Brian, Gonzalez, Frank J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1998
Soggetti:	Cell Growth and Development
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110684/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9566924/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.5.3059
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