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Molecular Evolution Allows Bypass of the Requirement for Activation Loop Phosphorylation of the Cdc28 Cyclin-Dependent Kinase

Many protein kinases are regulated by phosphorylation in the activation loop, which is required for enzymatic activity. Glutamic acid can substitute for phosphothreonine in some proteins activated by phosphorylation, but this substitution (T169E) at the site of activation loop phosphorylation in the...

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Main Authors: Cross, Frederick R., Levine, Kristi
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 1998
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC110671/
https://ncbi.nlm.nih.gov/pubmed/9566911
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