Human Lymphoblastoid CD4(+) T Cells Become Permissive to Macrophage-Tropic Strains of Human Immunodeficiency Virus Type 1 after Passage into Severe Combined Immunodeficient Mice through In Vivo Upregulation of CCR5: In Vivo Dynamics of CD4(+) T-Cell Differentiation in Pathogenesis of AIDS

In this article, we show that passage in SCID mice rendered a human CD4(+) T-cell line (CEM cells) highly susceptible to infection by macrophage-tropic (M-tropic) strains and primary clinical isolates of human immunodeficiency virus type 1 (HIV-1). This in vivo-acquired permissiveness of CEM cells w...

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Publicado en:	J Virol
Principais autores:	Lapenta, Caterina, Parlato, Stefania, Spada, Massimo, Santini, Stefano M., Rizza, Paola, Logozzi, Mariantonia, Proietti, Enrico, Belardelli, Filippo, Fais, Stefano
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1998
Assuntos:	Virus-Cell Interactions
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110622/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9811784/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.12.10323-10327.1998
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